Type VII collagen is a major structural component of anchoring fibrils.
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چکیده
منابع مشابه
Type VII collagen is a major structural component of anchoring fibrils
Anchoring fibrils are specialized fibrous structures found in the subbasal lamina underlying epithelia of several external tissues. Based upon their sensitivity to collagenase and the similarity in banding pattern to artificially created segment-long spacing crystallites (SLS) of collagens, several authors have suggested that anchoring fibrils are lateral aggregates of collagenous macromolecule...
متن کاملType VII collagen forms an extended network of anchoring fibrils
Type VII collagen is one of the newly identified members of the collagen family. A variety of evidence, including ultrastructural immunolocalization, has previously shown that type VII collagen is a major structural component of anchoring fibrils, found immediately beneath the lamina densa of many epithelia. In the present study, ultrastructural immunolocalization with monoclonal and monospecif...
متن کاملStructural investigations on native collagen type I fibrils using AFM.
This study was carried out to determine the elastic properties of single collagen type I fibrils with the use of atomic force microscopy (AFM). Native collagen fibrils were formed by self-assembly in vitro characterized with the AFM. To confirm the inner assembly of the collagen fibrils, the AFM was used as a microdissection tool. Native collagen type I fibrils were dissected and the inner core...
متن کاملDystrophic forms of epidermolysis bullosa (DEB) are associated with mutations in the type VII collagen gene (Col7a1) which encodes the major component of anchoring
Epidermolysis bullosa (EB) is a group of heritable mechanobullous disorders characterized by fragility of the skin and mucous membranes. Traditionally, EB has been divided into three broad categories based on the level of tissue separation within the cutaneous basement membrane zone (BMZ) (Christiano and Uitto, 1996a; Fine et al., 1999; Uitto et al., 1997). One of these subsets, the dystrophic ...
متن کاملA novel deletion and two recurrent substitutions on type VII collagen gene in seven Iranian patients with epidermolysis bullosa
Objective(s): Epidermolysis bullosa is one of the most important series of mechano-bullous heritable skin disorders which is categorized into four major types according to the layer that bullae forms within basement membrane zone. In dystrophic form of the disease, blisters are made in the sublamina densa zone, at the level of type VII collagen protein which produce anchoring fibrils. Type VII ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1986
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.103.4.1577